HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride → 2-Chloro-1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride | HCID 45075160 | — |
| Reactant | 2-chloro-1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester | HCID 71279254 | — |
| Product | 2-Chloro-1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester | HCID 71279240 | — |
Reaction Steps
The product was obtained starting from 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (125 mg, 504 μmol) and 2-chloro-1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (172 mg, 787 μmol) according to the method described in example 8, step 3 as purple solid (77 mg, 205 μmol, 40.7%). MS: M=376.3 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772510B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-fa1ce4851fde4adc9d879fe44f7d4d41 |
| Source note | uspto-grants-2014_07 |