Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1621095Generated: October 30, 2026

2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride → 2-Chloro-1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester

https://huagongshe.com/reaction/1621095

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochlorideHCID 45075160—
Reactant2-chloro-1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl esterHCID 71279254—
Product2-Chloro-1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl esterHCID 71279240—

Reaction Steps

The product was obtained starting from 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (125 mg, 504 μmol) and 2-chloro-1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (172 mg, 787 μmol) according to the method described in example 8, step 3 as purple solid (77 mg, 205 μmol, 40.7%). MS: M=376.3 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08772510B2
Source datasetuspto-grants-2014_07
ORD IDord-fa1ce4851fde4adc9d879fe44f7d4d41
Source noteuspto-grants-2014_07