Hydrochloric Acid → 2-(3-Phenyl-1H-1,2,4-triazol-1-yl)ethanamine dihydrochloride

HRID 1621105Notes

Reaction equation

HRID 1621105 reaction equation
[C:1]1([C:7]2[N:11]=[CH:10][N:9]([CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[C:1]1([C:7]2[N:11]=[CH:10][N:9]([CH2:12][CH2:13][NH2:14])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71279430tert-butyl 2-(3-phenyl-1H-1,2,4-triazol-1-yl)ethylcarbamate

Product 1

HCID 866774822-(3-Phenyl-1H-1,2,4-triazol-1-yl)ethanamine dihydrochlorideYield 98.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 2-(3-phenyl-1H-1,2,4-triazol-1-yl)ethylcarbamate (34 mg, 118 μmol) in dioxane (1 mL) was added hydrochloric acid (4M in dioxane, 590 μl, 2.36 mmol). The reaction mixture was stirred at RT for 18 h. All volatiles were removed in vacuo and the product was dried to yield a white solid (38 mg, 116 μmol, 98.7%) that was used without additional purification. MS: =189.3 M+H)+

Workup

  1. customAll volatiles were removed in vacuo
  2. customthe product was dried

Sources & evidence

ORD record
ord-d5d56fc9526b44bfb6791e9d44abbbf4
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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