HCID 21758136, compound → HCID 71279122, compound

HRID 1621113Notes

Reaction equation

HRID 1621113 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([CH3:14])[N:8]([CH3:13])[C:9]=1[C:10]([OH:12])=O)=[O:4].Cl.Cl.[CH3:17][N:18]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:20]=[C:19]1[CH2:29][CH2:30][NH2:31]>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([CH3:14])[N:8]([CH3:13])[C:9]=1[C:10](=[O:12])[NH:31][CH2:30][CH2:29][C:19]1[N:18]([CH3:17])[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:20]=1)=[O:4]

Participants

3

Reactant 2

HCID 21758136HCID 21758136, compoundHCID 86677477HCID 86677477, compound

Product 1

HCID 71279122HCID 71279122, compound

Conditions

Temperature
70 °C

Procedure

The product was obtained starting from 1,2-dimethyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (100 mg, 505 μmol; example 8, steps 1-2) and 2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethanamine dihydrochloride (152 mg, 555 μmol; example 7, steps 1-4) according to the method described in example 10, step 5 after stirring at 70° C. for 16 h, aqueous workup and purification as light yellow oil (111 mg, 291 μmol, 57.7%). MS: M=382.4 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-cd95c056627d4bf99a9fc28f766f9934
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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