Bromomethylcyclopropane → HCID 71279183, compound

HRID 1621116Notes

Reaction equation

C(OC([N:8]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:9][CH2:10][C:11]1[NH:15][N:14]=[C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:12]=1)=O)(C)(C)C.Br[CH2:30][CH:31]1[CH2:33][CH2:32]1>>[CH:31]1([CH2:30][N:15]2[C:11]([CH2:10][CH2:9][NH:8][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[N:12][C:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[N:14]2)[CH2:33][CH2:32]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 71279243HCID 71279243, compound

Product 1

HCID 71279183HCID 71279183, compound

Procedure

The product was obtained starting from 5-[2-bis(tert-butoxycarbonyl)aminoethyl]-3-phenyl-[1,2,4]triazole (250 mg, 644 μmol, example 22, step 1) and (bromomethyl)cyclopropane (104 mg, 73.9 μL, 772 μmol) according to the method described in example 34, step 1 as colorless oil (69 mg, 201 μmol, 31.3%).

Workup

customThe product was obtained

Sources & evidence

ORD record: ord-af6de37a68594956be0b7ae4fb7d7388
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772510B2

Reaction notes

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