Pyrrolidine → HCID 71288496, compound

HRID 1621120Notes

Reaction equation

[CH3:1][N:2]1[C:6]([C:7](=[O:23])[NH:8][CH2:9][CH2:10][C:11]2[N:12]=[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[O:14][C:15]=2[CH3:16])=[C:5]([C:24]([OH:26])=O)[CH:4]=[N:3]1.[NH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH3:16][C:15]1[O:14][C:13]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:12][C:11]=1[CH2:10][CH2:9][NH:8][C:7]([C:6]1[N:2]([CH3:1])[N:3]=[CH:4][C:5]=1[C:24]([N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)=[O:26])=[O:23]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 71279111HCID 71279111, compound

Product 1

HCID 71288496HCID 71288496, compound

Procedure

The product was obtained starting from 1-methyl-5-(2-(5-methyl-2-phenyloxazol-4-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylic acid (40 mg, 113 μmol) and pyrrolidine (8.03 mg, 9.34 μL, 113 μmol) according to the method described in example 37, step 3 as off-white solid (22.1 mg, 54.2 μmol, 48.0%).

Workup

customThe product was obtained

Sources & evidence

ORD record: ord-c76543d975d1488fa69f203a44897969
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08772510B2

Reaction notes

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