Methanesulfonyl chloride → HCID 86677488, compound

HRID 1621136Notes

Reaction equation

HRID 1621136 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([C:9]2[S:10][C:11]([CH3:17])=[C:12]([CH2:14][CH2:15][OH:16])[N:13]=2)[CH:6]=[CH:5][N:4]=1)[CH3:2].[CH3:18][S:19](Cl)(=[O:21])=[O:20]>>[CH3:18][S:19]([O:16][CH2:15][CH2:14][C:12]1[N:13]=[C:9]([C:7]2[CH:6]=[CH:5][N:4]=[C:3]([CH2:1][CH3:2])[CH:8]=2)[S:10][C:11]=1[CH3:17])(=[O:21])=[O:20]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 22563285HCID 22563285, compound

Product 1

HCID 86677488HCID 86677488, compound

Procedure

The product was obtained starting from 2-(2-(2-ethylpyridin-4-yl)-5-methylthiazol-4-yl)ethanol (200 mg, 805 μmol, prepared as described in WO 2003/037327) and methanesulfonyl chloride (111 mg, 75.3 μL, 966 μmol) according to the method described in example 46, step 1 as yellow oil (226 mg, 692 μmol, 86%) which was used without further purification for the next step.

Workup

  1. customThe product was obtained
  2. customwas used without further purification for the next step

Sources & evidence

ORD record
ord-5f03eba597a34f7390fde657b5dc1f81
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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