Triphenylphosphine → HCID 71279215, compound

HRID 1621138Notes

Reaction equation

HRID 1621138 reaction equation
[N:1]([CH2:4][CH2:5][C:6]1[N:7]=[C:8]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][CH3:19])[CH:13]=2)[S:9][C:10]=1[CH3:11])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[CH2:18]([C:14]1[CH:13]=[C:12]([C:8]2[S:9][C:10]([CH3:11])=[C:6]([CH2:5][CH2:4][NH2:1])[N:7]=2)[CH:17]=[CH:16][N:15]=1)[CH3:19]

Participants

3

Reactant 2

HCID 11776TriphenylphosphineHCID 71279134HCID 71279134, compound

Product 1

HCID 71279215HCID 71279215, compound

Procedure

The product was obtained starting from 4-(2-azidoethyl)-2-(2-ethylpyridin-4-yl)-5-methylthiazole (134 mg, 490 μmol) and triphenylphosphine polymer bound (248 mg, 735 μmol) according to the method described in example 46, step 3 as yellow oil (117 mg, 473 μmol, 96.5%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-9e81adcf7f634983b83aba201ca3695e
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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