HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 2-Methyl-4-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(1-methyl-1H-benzo imidazol-2-yl)-ethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 1-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylic acid | HCID 71279171 | — |
| Product | 2-Methyl-4-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(1-methyl-1H-benzo imidazol-2-yl)-ethyl]-amide | HCID 71288597 | — |
Reaction Steps
The product was obtained starting from 1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylic acid (25 mg, 76.4 μmol) and pyrrolidine (6.52 mg, 7.58 μL, 91.6 μmol) according to the method described in example 37, step 3 as light red solid (15 mg, 39.4 μmol, 51.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772510B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-4e71e75a0d49491cae697917ce41a988 |
| Source note | uspto-grants-2014_07 |