Pyrrolidine → 2-Methyl-4-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(1-methyl-1H-benzo imidazol-2-yl)-ethyl]-amide

HRID 1621142Notes

Reaction equation

HRID 1621142 reaction equation
[CH3:1][N:2]1[C:6]([C:7](=[O:21])[NH:8][CH2:9][CH2:10][C:11]2[N:15]([CH3:16])[C:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=3[N:12]=2)=[C:5]([C:22](O)=[O:23])[CH:4]=[N:3]1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH3:16][N:15]1[C:14]2[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=2[N:12]=[C:11]1[CH2:10][CH2:9][NH:8][C:7]([C:6]1[N:2]([CH3:1])[N:3]=[CH:4][C:5]=1[C:22]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:23])=[O:21]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 712791711-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 712885972-Methyl-4-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid [2-(1-methyl-1H-benzo imidazol-2-yl)-ethyl]-amide

Procedure

The product was obtained starting from 1-methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-pyrazole-4-carboxylic acid (25 mg, 76.4 μmol) and pyrrolidine (6.52 mg, 7.58 μL, 91.6 μmol) according to the method described in example 37, step 3 as light red solid (15 mg, 39.4 μmol, 51.6%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-4e71e75a0d49491cae697917ce41a988
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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