HCID 21758136, compound → HCID 71279172, compound

HRID 1621146Notes

Reaction equation

HRID 1621146 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[N:7][N:8]([CH3:13])[C:9]=1[C:10]([O-:12])=O)=[O:4].[Li+].Cl.Cl.[CH3:17][N:18]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:20]=[C:19]1[CH2:29][CH2:30][NH2:31]>>[CH3:13][N:8]1[C:9]([C:10](=[O:12])[NH:31][CH2:30][CH2:29][C:19]2[N:18]([CH3:17])[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:20]=2)=[C:5]([C:3]([O:2][CH3:1])=[O:4])[N:6]=[N:7]1

Participants

3

Reactant 2

HCID 21758136HCID 21758136, compoundHCID 86677489HCID 86677489, compound

Product 1

HCID 71279172HCID 71279172, compound

Procedure

The product was obtained starting from lithium 4-(methoxycarbonyl)-1-methyl-1H-1,2,3-triazole-5-carboxylate (150 mg, 785 μmol) and 2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethanamine dihydrochloride (226 mg, 824 μmol, example 7, step 4) according to the method described in example 7, step 5 after aqueous work-up and purification by flash chromatography (using silica gel and an ethyl acetate/heptane gradient) as light yellow solid (79 mg, 214 μmol, 27.3%).

Workup

  1. customThe product was obtained
  2. customafter aqueous work-up and purification by flash chromatography (

Sources & evidence

ORD record
ord-350a20c0bd644ea7ba1d97449df45ff2
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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