反应详情

温度

60 °C

A mixture of 5-(bromomethyl)-1,3-diphenyl-1H-1,2,4-triazole (265 mg, 843 μmol) and potassium cyanide (62.3 mg, 928 μmol) in DMSO (5 mL) was heated at 60° C. for 1.5 h. The reaction mixture was cooled to RT, poured into water (25 mL) and extracted with ethyl acetate (2×50 mL). The organic phases were washed with water (2×25 mL) and brine (1×25 mL), and the combined organic layer was dried over MgSO4 and concentrated in vacuo to give 251 mg of crude product. The product was obtained after purification by flash chromatography (using silica gel and an ethyl acetate/heptane gradient) as light yellow waxy solid (120 mg, 461 μmol, 54.7%).

1. temperatureThe reaction mixture was cooled to RT
2. extractionextracted with ethyl acetate (2×50 mL)
3. washThe organic phases were washed with water (2×25 mL) and brine (1×25 mL)
4. dry with materialthe combined organic layer was dried over MgSO4
5. concentrationconcentrated in vacuo