HCID 21758136, compound → HCID 71279099, compound

HRID 1621166Notes

Reaction equation

HRID 1621166 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]([C:14]([F:17])([F:16])[F:15])[N:8]([CH3:13])[C:9]=1[C:10]([OH:12])=O)=[O:4].Cl.Cl.[CH3:20][N:21]1[CH:25]=[C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:23]=[C:22]1[CH2:32][CH2:33][NH2:34]>>[CH3:13][N:8]1[C:9]([C:10](=[O:12])[NH:34][CH2:33][CH2:32][C:22]2[N:21]([CH3:20])[CH:25]=[C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:23]=2)=[C:5]([C:3]([O:2][CH3:1])=[O:4])[N:6]=[C:7]1[C:14]([F:17])([F:16])[F:15]

Participants

3

Reactant 2

HCID 21758136HCID 21758136, compoundHCID 71279098HCID 71279098, compound

Product 1

HCID 71279099HCID 71279099, compound

Procedure

The product was obtained starting from 4-(methoxycarbonyl)-1-methyl-2-(trifluoromethyl)-1H-imidazole-5-carboxylic acid (200 mg, 793 μmol) and 2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethanamine hydrochloride (226 mg, 952 μmol, example 7, step 4) according to the method described in example 7, step 5 after aqueous work-up and purification by flash chromatography (using silica gel and an ethyl acetate/heptane gradient) as white foam (128 mg, 294 μmol, 37.1%).

Workup

  1. customThe product was obtained
  2. customafter aqueous work-up and purification by flash chromatography (

Sources & evidence

ORD record
ord-fa1e9d7d334c4d3cb68b1d19bc66bdc7
Source dataset
uspto-grants-2014_07
Patent number
US08772510B2

Reaction notes

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