Hydrochloric Acid → HCID 178511219, compound

Participants

Reaction Conditions

Reaction Steps

In the reaction vessel purged with nitrogen, 580 g (4.47 moles) of hydrochloride of 3-chloropropylamine was added, and 1048 mL of water was further added thereto to dissolve hydrochloride of 3-chloropropylamine. The obtained solution was kept at from 60° C. to 70° C., and 1164 g (4.69 moles) of pentahydrate of sodium thiosulfate was added thereto. The total used amount of water was 1470 g (the total of 1048 g of water and 422 g of water contained in pentahydrate of sodium thiosulfate). The solution was stirred for 4 hours while the reaction vessel was heated at a bath temperature of 80° C. After 2 hours, a little amount of solid was precipitated. The obtained reaction mixture was cooled, and then stirred overnight at room temperature. The obtained mixture was filtrated to afford the solid mainly containing S-(3-aminopropyl)thiosulfuric acid.

Provenance & Evidence