Hydrochloric Acid → HCID 178511219, compound

Temperature

80 °C

In the reaction vessel purged with nitrogen, 580 g (4.47 moles) of hydrochloride of 3-chloropropylamine was added, and 1048 mL of water was further added thereto to dissolve hydrochloride of 3-chloropropylamine. The obtained solution was kept at from 60° C. to 70° C., and 1164 g (4.69 moles) of pentahydrate of sodium thiosulfate was added thereto. The total used amount of water was 1470 g (the total of 1048 g of water and 422 g of water contained in pentahydrate of sodium thiosulfate). The solution was stirred for 4 hours while the reaction vessel was heated at a bath temperature of 80° C. After 2 hours, a little amount of solid was precipitated. The obtained reaction mixture was cooled, and then stirred overnight at room temperature. The obtained mixture was filtrated to afford the solid mainly containing S-(3-aminopropyl)thiosulfuric acid.

1. additionwas added
2. additionwas added
3. waitAfter 2 hours
4. customa little amount of solid was precipitated
5. customThe obtained reaction mixture
6. temperaturewas cooled
7. stirringstirred overnight at room temperature
8. filtrationThe obtained mixture was filtrated

ORD record

ord-3ceb5331d3e44b158dae4be414fe3ccc

Source dataset

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08772537B2