4-Fluoro-3-methylbenzaldehyde → 6-fluoro-2-(4-methoxybenzyl)-7-methylisoquinolin-1(2H)-one

HRID 1621294Notes

Reaction equation

HRID 1621294 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=[O:6].ClC1C=C2C([CH:16]=[CH:17][N:18]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)C2=O)=CC=1F>>[F:10][C:9]1[CH:8]=[C:7]2[C:4](=[CH:3][C:2]=1[CH3:1])[C:5](=[O:6])[N:18]([CH2:23][C:24]1[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=1)[CH:17]=[CH:16]2

Participants

3

Reactant 2

HCID 27348744-Fluoro-3-methylbenzaldehydeHCID 598182477-Chloro-6-fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1(2H)-one

Product 1

HCID 592260436-fluoro-2-(4-methoxybenzyl)-7-methylisoquinolin-1(2H)-one

Procedure

Starting from 3-methyl-4-fluoro benzaldehyde, the title compound was prepared following a similar sequence as described for 7-chloro-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (62). Rt=1.83 min (Method B). Detected mass: 298.1 (M+H+).

Sources & evidence

ORD record
ord-e58da68ef1fd4a0fb34c5e99a53c6ce5
Source dataset
uspto-grants-2014_07
Patent number
US08772492B2

Reaction notes

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