Iodine → 2-(2,5-Dibromophenyl)benzo[d]thiazole

HRID 1621309Notes

Reaction equation

HRID 1621309 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][C:3]=1[CH:4]=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[SH:18].II>CN(C=O)C>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][C:3]=1[C:4]1[S:18][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]=1

Participants

5

Reactant 3

HCID 807IodineHCID 87132-AminothiophenolHCID 135400692,5-Dibromobenzaldehyde

Product 1

HCID 584799632-(2,5-Dibromophenyl)benzo[d]thiazole

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5 g (18.5 mmol) of 2,5-dibromobenzaldehyde, 3 mL (27.7 mmol) of 2-aminothiophenol, and 2.35 g (9.25 mmol) of iodine were dissolved in 100 mL of DMF. The solution was reacted at 100° C. for 1 hour. The obtained reactant was purified through a column, obtaining 4.64 g (Y=68%) of a white solid.

Workup

  1. customThe solution was reacted at 100° C. for 1 hour
  2. customThe obtained reactant was purified through a column
  3. customobtaining 4.64 g (Y=68%) of a white solid

Sources & evidence

ORD record
ord-37883f45c01f4c958b3de168b018472d
Source dataset
uspto-grants-2014_07
Patent number
US08772632B2

Reaction notes

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