Tetrahydrofuran → Ethyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinate

HRID 162155Notes

Reaction equation

HRID 162155 reaction equation
[Br:17][N:18]1[C:19](=[O:20])[CH2:21][CH2:22][C:23]1=[O:24].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([C:13]([F:14])([F:15])[F:16])[nH:8][c:9](=[O:12])[cH:10][cH:11]1.[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([C:13]([F:14])([F:15])[F:16])[nH:8][c:9](=[O:12])[c:10]([Br:17])[cH:11]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 67184N-bromobutanimideHCID 18374262Ethyl 6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylate

Product 1

HCID 57900861Ethyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinate

Sources & evidence

ORD record
ord-99aedf1ed21e441784821a8dbfbffe1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…