5-Fluoro-6-methoxypyridin-3-amine → HCID 59548162, compound

HRID 1621772Notes

Reaction equation

HRID 1621772 reaction equation
F[C:2]1[C:7]([C:8]2[N:13]=[C:12]([CH3:14])[N:11]=[C:10]([N:15](CC3C=CC(OC)=CC=3)CC3C=CC(OC)=CC=3)[N:9]=2)=[CH:6][CH:5]=[C:4]([O:34][CH2:35][CH2:36][O:37][CH3:38])[N:3]=1.[F:39][C:40]1[CH:41]=[C:42]([NH2:48])[CH:43]=[N:44][C:45]=1[O:46][CH3:47]>>[F:39][C:40]1[CH:41]=[C:42]([NH:48][C:2]2[C:7]([C:8]3[N:13]=[C:12]([CH3:14])[N:11]=[C:10]([NH2:15])[N:9]=3)=[CH:6][CH:5]=[C:4]([O:34][CH2:35][CH2:36][O:37][CH3:38])[N:3]=2)[CH:43]=[N:44][C:45]=1[O:46][CH3:47]

Participants

3

Reactant 2

HCID 454803515-Fluoro-6-methoxypyridin-3-amineHCID 66612086HCID 66612086, compound

Product 1

HCID 59548162HCID 59548162, compound

Procedure

The title compound was prepared in an analogous manner to that described in Example 254 using 4-(2-fluoro-6-(2-methoxyethoxy)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine and 5-fluoro-6-methoxypyridin-3-amine (Anichem), and was isolated as yellow amorphous powder (4.9%). m/z (ESI, +ve ion) 402.0 (M+H)+. 1H NMR (400 MHz, d4-MeOH) δ 12.15 (1H, br. s.); 8.77 (1H, d, J=8.6 Hz); 8.32 (1H, br. s.); 8.15 (1H, br. s.); 6.30 (1H, s); 3.98 (3H, s); 3.72 (2H, br. s.); 3.37 (4H, s); 2.44 (4H, s).

Sources & evidence

ORD record
ord-4d3253c2fa2543529ec5c91233a4cc3f
Source dataset
uspto-grants-2014_07
Patent number
US08772480B2

Reaction notes

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