HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 1-(5-(5-Fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 1-(5-(5-Fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)ethanone | HCID 66600079 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(5-(5-Fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)ethanone | HCID 66599857 | — |
Reaction Steps
A mixture of 1-(5-(5-fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)ethanone (52 mg, 0.130 mmol) and 3-chloroperoxybenzoic acid (44.8 mg, 0.260 mmol, Aldrich, St. Louis, Mo.) in dioxane (1 mL) was stirred at room temperature for 2 h. The mixture was taken on directly to the next step without work-up.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08772480B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-d9f0b6f5ad034b6dad5a054072b1d579 |
| Source note | uspto-grants-2014_07 |