m-Chloroperbenzoic acid → 1-(5-(5-Fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)ethanone

HRID 1621828Notes

Reaction equation

HRID 1621828 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:12]=[CH:13][C:14]([C:26](=[O:28])[CH3:27])=[N:15][C:16]=2[C:17]2[CH:22]=[C:21]([S:23][CH3:24])[N:20]=[C:19]([CH3:25])[N:18]=2)[CH:5]=[N:6][C:7]=1[O:8][CH3:9].ClC1C=C(C=CC=1)C(OO)=[O:34]>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[N:12]=[CH:13][C:14]([C:26](=[O:28])[CH3:27])=[N:15][C:16]=2[C:17]2[CH:22]=[C:21]([S:23]([CH3:24])=[O:34])[N:20]=[C:19]([CH3:25])[N:18]=2)[CH:5]=[N:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 666000791-(5-(5-Fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)ethanone

Product 1

HCID 665998571-(5-(5-Fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylsulfinyl)pyrimidin-4-YL)pyrazin-2-YL)ethanone

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 1-(5-(5-fluoro-6-methoxypyridin-3-ylamino)-6-(2-methyl-6-(methylthio)pyrimidin-4-yl)pyrazin-2-yl)ethanone (52 mg, 0.130 mmol) and 3-chloroperoxybenzoic acid (44.8 mg, 0.260 mmol, Aldrich, St. Louis, Mo.) in dioxane (1 mL) was stirred at room temperature for 2 h. The mixture was taken on directly to the next step without work-up.

Sources & evidence

ORD record
ord-d9f0b6f5ad034b6dad5a054072b1d579
Source dataset
uspto-grants-2014_07
Patent number
US08772480B2

Reaction notes

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