2-(2-Fluoro-(1,1'-biphenyl)-4-yl)acetic acid → HCID 69669860, compound

HRID 1622038Notes

Reaction equation

HRID 1622038 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CC(C)CO>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9]([O:11][CH2:2][CH:3]([CH3:12])[CH3:4])=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 1

HCID 118312372-(2-Fluoro-(1,1'-biphenyl)-4-yl)acetic acid

Product 1

HCID 69669860HCID 69669860, compound

Reagents, catalysts & solvents 1

HCID 6560IsobutanolSolvent

Procedure

2-methylpropyl 2-(2-fluorobiphenyl-4-yl)acetate (24) was synthesized from 2-(2-fluorobiphenyl-4-yl)acetic acid and 2-methyl propanol according to a similar procedure to step 1 of Example 15. The 1H NMR spectrum of this substance is shown below.

Sources & evidence

ORD record
ord-c3f9f3be1d744a4b91901d426b7b19ef
Source dataset
uspto-grants-2014_07
Patent number
US08778298B2

Reaction notes

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