Hydroxyamine hydrochloride → HCID 178504864, compound

HRID 1622234Notes

Reaction equation

[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[C:14]3[CH2:20][CH:19]([CH:21]4[CH2:26][CH2:25][N:24]([C:27]#[N:28])[CH2:23][CH2:22]4)[O:18][C:15]3=[CH:16][N:17]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl.[NH2:30][OH:31]>>[OH:31][NH:30][C:27]([N:24]1[CH2:25][CH2:26][CH:21]([CH:19]2[O:18][C:15]3=[CH:16][N:17]=[C:12]([C:9]4[CH:10]=[CH:11][C:6]([CH2:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:7][CH:8]=4)[CH:13]=[C:14]3[CH2:20]2)[CH2:22][CH2:23]1)=[NH:28]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 89372981HCID 89372981, compound

Product 1

HCID 178504864HCID 178504864, compound

Procedure

The title compound is prepared from 4-[5-(4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile and hydroxylamine hydrochloride following a procedure analogous to that described for Intermediate 11. LC (method 5): tR=0.83 min; Mass spectrum (ESI+): m/z=431 [M+H]+.

Sources & evidence

ORD record: ord-f69d0bab2a5344529fa8bdd05a87879b
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778926B2

Reaction notes

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