Hydroxyamine hydrochloride → HCID 178504865, compound

HRID 1622238Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[C:15]2[CH2:21][CH:20]([CH:22]3[CH2:27][CH2:26][N:25]([C:28]#[N:29])[CH2:24][CH2:23]3)[O:19][C:16]2=[CH:17][N:18]=1.Cl.[NH2:31][OH:32]>>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[C:15]2[CH2:21][CH:20]([CH:22]3[CH2:27][CH2:26][N:25]([C:28]([NH:31][OH:32])=[NH:29])[CH2:24][CH2:23]3)[O:19][C:16]2=[CH:17][N:18]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 89372974HCID 89372974, compound

Product 1

HCID 178504865HCID 178504865, compound

Procedure

The title compound is prepared from 4-[5-(2-fluoro-4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile and hydroxylamine hydrochloride following a procedure analogous to that described for Intermediate 11. LC (method 6): tR=0.90 min; Mass spectrum (ESI+): m/z=449 [M+H]+.

Sources & evidence

ORD record: ord-524757f535464d33b3259ae9439834f3
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778926B2

Reaction notes

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