4-(Methanesulfonyl)phenylboronic acid → (S)-4-[5-(4-Methanesulfonyl-phenyl)-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

The title compound is prepared from (S)-4-(5-chloro-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 29; the configuration of the stereocenter is arbitrarily assigned) and 4-(methanesulfonyl)phenylboronic acid following a procedure analogous to that described for Intermediate 7. LC (method 4): tR=1.19 min; Mass spectrum (ESI+): m/z=473 [m+H]+.

Provenance & Evidence