反应详情

3-(1-Nitro-2-naphthylamino)benzonitrile (1.16 g, 3.99 mmol) was hydrogenated in methanol (20 mL)/THF (40 mL) for 4 hours at room temperature using 10% palladium-carbon (220 mg) as a catalyst. After removal of the catalyst by filtration, the filtrate was concentrated to dryness. The residue was purified by silica gel column chromatography (chloroform/methanol=99/1), to give the titled compound as a yellow crystal (968 mg, yield 93%).

1. customfor 4 hours
2. customat room temperature
3. customAfter removal of the catalyst
4. filtrationby filtration
5. concentrationthe filtrate was concentrated to dryness
6. customThe residue was purified by silica gel column chromatography (chloroform/methanol=99/1)