5-Chloropyrimidin-2-ol hydrochloride → HCID 86656267, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-chloropyrimidone hydrochloride (1.0 g, 6.0 mmol) in phosphorous oxychloride (4 mL) was heated at 90° C. for 90 min then cooled to room temperature and filtered. The crude product was purified by sublimation under reduced pressure to furnish the title compound 20 as a crystalline white solid (273 mg). This compound was unstable to air and was used immediately in the next step.

Provenance & Evidence