5-Chloropyrimidin-2-ol hydrochloride → HCID 86656267, compound
Reaction equation
[ClH:1].[Cl:2][C:3]1[CH:4]=[N:5][C:6](=O)[NH:7][CH:8]=1>P(Cl)(Cl)(Cl)=O>[ClH:2].[Cl:1][C:4]1[C:3]([Cl:2])=[CH:8][N:7]=[CH:6][N:5]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
A suspension of 5-chloropyrimidone hydrochloride (1.0 g, 6.0 mmol) in phosphorous oxychloride (4 mL) was heated at 90° C. for 90 min then cooled to room temperature and filtered. The crude product was purified by sublimation under reduced pressure to furnish the title compound 20 as a crystalline white solid (273 mg). This compound was unstable to air and was used immediately in the next step.
Workup
- temperaturethen cooled to room temperature
- filtrationfiltered
- customThe crude product was purified by sublimation under reduced pressure
Sources & evidence
- ORD record
- ord-66c7e9f71e6c4492959479999701a1c7
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08778925B2
Reaction notes
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