Sodium Carbonate → 1-(3-Chloro-5-(4-methoxyphenyl)pyridin-4-yl)piperidine-4-carboxamide

Participants

Reaction Steps

General procedure D (See Example 4) was followed using 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide (24 mg, 0.088 mmol), 4-methoxybenzene boronic acid (16 mg, 0.11 mmol), tetrakis(triphenylphosphine)palladium(0) (5 mg, 5 mol %), acetonitrile (1 mL) and 0.5 M sodium carbonate (0.25 mL, 0.12 mmol) for 30 min. The crude product was purified by preparative hplc (CH3CN, H2O, 23:77) to furnish the title compound as a white solid (9 mg, 30%), LC-MS (ESI) Rt 1.67 min, m/z 346 (100%, [M+H]+); m/z (ESI) C18H21ClN3O2 requires 346.1317 found [M+H]+ 346.1317.

Provenance & Evidence