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HRID1622367

反应详情

EQUATION

反应方程式

HRID 1622367 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：COc1ccc(B(O)O)cc1
HCID201262

Benzeneboronic acid, p-methoxy-

C7H9BO3

结构：NC(=O)C1CCN(c2c(Cl)cncc2Cl)CC1
HCID2811640

1-(3,5-Dichloro-4-pyridinyl)-4-piperidinecarboxamide

C11H13Cl2N3O

PRODUCTS

生成物

1
结构：COc1ccc(-c2cncc(Cl)c2N2CCC(C(N)=O)CC2)cc1
HCID45136844

未命名化合物

收率 30%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

General procedure D (See Example 4) was followed using 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide (24 mg, 0.088 mmol), 4-methoxybenzene boronic acid (16 mg, 0.11 mmol), tetrakis(triphenylphosphine)palladium(0) (5 mg, 5 mol %), acetonitrile (1 mL) and 0.5 M sodium carbonate (0.25 mL, 0.12 mmol) for 30 min. The crude product was purified by preparative hplc (CH3CN, H2O, 23:77) to furnish the title compound as a white solid (9 mg, 30%), LC-MS (ESI) Rt 1.67 min, m/z 346 (100%, [M+H]+); m/z (ESI) C18H21ClN3O2 requires 346.1317 found [M+H]+ 346.1317.

WORKUP

后处理

  1. customfor 30 min
  2. customThe crude product was purified by preparative hplc (CH3CN, H2O, 23:77)