反应详情

To a suspension of NaH (60%, 143 mg) in THF (dry) (15 mL) was added 2-chloroethanesulfonyl chloride (0.376 mL) at 0° C. and the mixture was stirred for 5 min at the same temperature. A solution of 3-(4-(3-methoxyphenoxy)phenyl)pyridin-2-amine (348 mg) in THF (dry) (15 mL) was added at 0° C. and the mixture was stirred at room temperature under nitrogen for 15 hr. The mixture was quenched with water at 0° C. carefully and water was added to form precipitates. The precipitate was crystallized from MeCN-THF-MeOH/IPE to give the title compound (304 mg) as colorless crystals.

1. stirringthe mixture was stirred at room temperature under nitrogen for 15 hr
2. customThe mixture was quenched with water at 0° C. carefully
3. additionwater was added
4. customto form
5. customprecipitates
6. customThe precipitate was crystallized from MeCN-THF-MeOH/IPE