HCID 66747936, compound → HCID 66748382, compound

HRID 1622831Notes

Reaction equation

HRID 1622831 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:19]3=[N:20][S:21](=[O:25])(=[O:24])[CH2:22][CH2:23][N:18]3[CH:17]=[CH:16][N:15]=2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCO.[Pt](=O)=O>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[C:19]3=[N:20][S:21](=[O:25])(=[O:24])[CH2:22][CH2:23][N:18]3[CH2:17][CH2:16][NH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 66747936HCID 66747936, compound

Product 1

HCID 66748382HCID 66748382, compoundYield 33%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 9-(4-phenoxyphenyl)-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide (96.0 mg), and platinum(IV) oxide (15.0 mg) in EtOH (5 mL) was stirred at room temperature for 2.5 hr under H2. The mixture was added with NH silica gel, concentrated, purified by column chromatography (NH silica gel, eluted with MeOH in EtOAc), then recrystallized from EtOAc-IPE to give the title compound (32.0 mg) as white powder.

Workup

  1. additionThe mixture was added with NH silica gel
  2. concentrationconcentrated
  3. custompurified by column chromatography (NH silica gel, eluted with MeOH in EtOAc)
  4. customrecrystallized from EtOAc-IPE

Sources & evidence

ORD record
ord-852aa4af20bf4cce99472cb5cd6c4cd0
Source dataset
uspto-grants-2014_07
Patent number
US08778934B2

Reaction notes

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