Hydrogen chloride-ethyl acetate → HCID 66823906, compound

HRID 1622869Notes

Reaction equation

HRID 1622869 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]2([CH3:27])[C:13]3=[N:14][S:15](=[O:19])(=[O:18])[CH2:16][CH2:17][N:12]3[CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)[CH:5]=[CH:4][C:3]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[ClH:34].CCOC(C)=O>CCOC(C)=O>[ClH:34].[F:1][C:2]1[CH:7]=[C:6]([C:8]2([CH3:27])[C:13]3=[N:14][S:15](=[O:19])(=[O:18])[CH2:16][CH2:17][N:12]3[CH2:11][CH2:10][NH:9]2)[CH:5]=[CH:4][C:3]=1[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66747758HCID 66747758, compound

Product 1

HCID 66823906HCID 66823906, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A suspension of tert-butyl 9-(2-fluorobiphenyl-4-yl)-9-methyl-3,4,6,7-tetrahydropyrazino[2,1-c][1,2,4]thiadiazine-8(9H)-carboxylate 2,2-dioxide (150 mg) and 4 N HCl/EtOAc (5 ml) in EtOAc (5 mL) was stirred at room temperature overnight. After removing solvent, the residue was recrystallized from MeOH to give the title compound (65 mg) as a white solid.

Workup

  1. customAfter removing solvent
  2. customthe residue was recrystallized from MeOH

Sources & evidence

ORD record
ord-1ad4bd89c33241d1a8c58c2d4c8e2e7f
Source dataset
uspto-grants-2014_07
Patent number
US08778934B2

Reaction notes

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