反应详情

温度

5 °C

To a stirred solution of 5-fluoro-1H-pyrrolo[2,3-b]pyridine (5.00 g, 36.73 mmol) in Et2O (120 mL), under a nitrogen atmosphere, is added 3-chloroperoxybenzoic acid (11.09 g, 64.28 mmol) portionwise over 5 minutes and the reaction stirred for 3 h. The reaction is then cooled to 5° C., filtered and the solid washed with Et2O (ca. 100 mL). This is dried in vacuo to give the title compound as a pale green crystalline solid (4.317 g, 28.38 mmol). MS (m/z): 153 (M+1).

1. filtrationfiltered
2. washthe solid washed with Et2O (ca. 100 mL)
3. customThis is dried in vacuo