Oxalic acid dihydrate → HCID 131731666, compound

HRID 1623054Notes

Reaction equation

HRID 1623054 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:23][CH2:22][C@:12]34[C:13]5[C:14]6[O:21][C@H:11]3[C@H:10]([N:24]([CH3:34])[C:25](=[O:33])/[CH:26]=[CH:27]/[C:28]3[CH:32]=[CH:31][O:30][CH:29]=3)[CH2:9][CH2:8][C@@:7]4([OH:35])[C@H:6]2[CH2:19][C:18]=5[CH:17]=[CH:16][C:15]=6[OH:20])[CH2:3][CH2:2]1.O.O.[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40]>CO.O>[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40].[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40].[CH:1]1([CH2:4][N:5]2[CH2:23][CH2:22][C@:12]34[C:13]5[C:14]6[O:21][C@H:11]3[C@H:10]([N:24]([CH3:34])[C:25](=[O:33])/[CH:26]=[CH:27]/[C:28]3[CH:32]=[CH:31][O:30][CH:29]=3)[CH2:9][CH2:8][C@@:7]4([OH:35])[C@H:6]2[CH2:19][C:18]=5[CH:17]=[CH:16][C:15]=6[OH:20])[CH2:2][CH2:3]1

Participants

5

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 6445230(E)-N-(17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6beta-yl)-3-(furan-3-yl)-N-methylprop-2-enamide

Product 1

HCID 131731666HCID 131731666, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Compound 20b was converted to its oxalic salt using one equivalent of oxalic acid dihydrate in methanol. Solubility: 32.0 mg/mL in H2O.

Sources & evidence

ORD record
ord-22bf55cd28364a639d7f71554a955462
Source dataset
uspto-grants-2014_07
Patent number
US08778958B2

Reaction notes

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