HCID 86052868, compound → HCID 86612248, compound

HRID 1623115Notes

Reaction equation

HRID 1623115 reaction equation
[CH3:1][O:2][N:3]=[CH:4][CH2:5][CH2:6][CH2:7][N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]=[CH:12][C:11]=2[N:10]=[C:9]1[CH2:21][CH2:22][CH3:23].CO[N:26](CCCCN1C2C3C=CC=CC=3N=CC=2N=C1CCC)C(=O)C>>[CH3:1][O:2][N:3]=[CH:4][CH2:5][CH2:6][CH2:7][N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]=[C:12]([NH2:26])[C:11]=2[N:10]=[C:9]1[CH2:21][CH2:22][CH3:23]

Participants

3

Reactant 2

HCID 86052868HCID 86052868, compoundHCID 86612247HCID 86612247, compound

Product 1

HCID 86612248HCID 86612248, compound

Procedure

The general method of Part G of Example 6 was followed using 4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyraldehyde O-methyloxime (17.5 g, 56.5 mmol), prepared as described in Parts A-D of Example 6, in lieu of N-methoxy-N-[4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]acetamide. Purification by flash column chromatography on silica gel afforded 11.4 g of 4-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyraldehyde O-methyloxime.

Workup

  1. customprepared
  2. customPurification by flash column chromatography on silica gel

Sources & evidence

ORD record
ord-101e261d282b41879a1f1cf8cd10e383
Source dataset
uspto-grants-2014_07
Patent number
US08778963B2

Reaction notes

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