HCID 57464096, compound → HCID 57455394, compound

HRID 1623118Notes

Reaction equation

HRID 1623118 reaction equation
[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][CH2:19][CH:20]=[O:21])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3].N[C:23]1C2N=C(CCCC)N(CCCC(N(OC)C)=O)C=2C2N=CC=CC=2N=1>>[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][CH2:19][CH:20]([OH:21])[CH3:23])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 57464096HCID 57464096, compound2×HCID 86612246HCID 86612246, compound

Product 1

HCID 57455394HCID 57455394, compound

Procedure

The preparation of 4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyraldehyde is described in parts A-C of Example 6. The general procedure of Part G of Example 4 was repeated using 4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyraldehyde (6.4 g, 22.74 mmol) in lieu of 4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)-N-methoxy-N-methylbutanamide to provide 5.2 g of 5-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)pentan-2-ol as a tan oil.

Sources & evidence

ORD record
ord-137aed4e806e4145b545c7db55c19f59
Source dataset
uspto-grants-2014_07
Patent number
US08778963B2

Reaction notes

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