HCID 57455389, compound → HCID 69507057, compound

HRID 1623144Notes

Reaction equation

HRID 1623144 reaction equation
[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][CH2:19][C:20]([O:22]CC)=O)[C:6]2[C:15]3[N:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3].[CH2:25](C1N(CCCC(OCC)=O)C2C3N=CC=CC=3N=CC=2N=1)CCC>>[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][CH2:19][C:20](=[O:22])[CH3:25])[C:6]2[C:15]3[N:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 57455389HCID 57455389, compoundHCID 57455398HCID 57455398, compound

Product 1

HCID 69507057HCID 69507057, compound

Procedure

A modified version of the general methods described in Parts D-G of Example 4 was sequentially followed with ethyl 4-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyrate (6.0 g, 18.4 mmol) used in lieu of ethyl 4-(2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyrate as the starting substrate. Isolation after the last step of the sequence afforded 6.06 g of crude 5-(2-propyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)pentan-2-one.

Sources & evidence

ORD record
ord-8fde47119c094c88aa0b8eda1dd8e427
Source dataset
uspto-grants-2014_07
Patent number
US08778963B2

Reaction notes

Loading…