Hydrochloric Acid → HCID 24965782, compound

HRID 1623188Notes

Reaction equation

HRID 1623188 reaction equation
[CH3:1][C:2]([CH3:26])([CH2:19][C:20]1([CH3:25])OCC[O:21]1)[CH2:3][N:4]1[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:17])[C:7]=2[N:6]=[C:5]1[CH3:18].Cl>>[NH2:17][C:8]1[C:7]2[N:6]=[C:5]([CH3:18])[N:4]([CH2:3][C:2]([CH3:26])([CH3:1])[CH2:19][C:20](=[O:21])[CH3:25])[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58837342HCID 58837342, compound

Product 1

HCID 24965782HCID 24965782, compound

Procedure

By the general method of Part E of Example 30, 1-[2,2-dimethyl-3-(2-methyl-[1,3]dioxolan-2-yl)propyl]-2-methyl-1H-imidazo[4,5-c]quinolin-4-amine was hydrolyzed with aqueous hydrochloric acid to provide 5-(4-amino-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one as a light brown solid after recrystallization from aqueous acetonitrile, mp 223-225° C.

Sources & evidence

ORD record
ord-5cfb37fae0d74b0082009b985df61622
Source dataset
uspto-grants-2014_07
Patent number
US08778963B2

Reaction notes

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