Hydrochloric Acid → HCID 178511265, compound

HRID 1623275Notes

Reaction equation

HRID 1623275 reaction equation
[Cl:1][C:2]1[C:3]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[N:25]=2)=[CH:4][C:5]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([CH2:15][NH:16]C(=O)OC(C)(C)C)[CH2:11][CH2:10]2)=[N:6][CH:7]=1.Cl.O1CCOCC1>>[NH2:16][CH2:15][C@H:12]1[CH2:11][CH2:10][C@H:9]([NH:8][C:5]2[CH:4]=[C:3]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[N:25]=3)[C:2]([Cl:1])=[CH:7][N:6]=2)[CH2:14][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178453634HCID 178453634, compound

Product 1

HCID 178511265HCID 178511265, compoundYield 111.5%

Procedure

A mixture of tert-butyl (trans-4-(5′-chloro-6-fluoro-2,4′-bipyridin-2′-yl-amino)cyclohexyl)methylcarbamate (390 mg, 0.897 mmol), 4M HCl in Dioxane (5604 μl, 22.42 mmol) reaction mixture was stirred at ambient temperature for 1 hr. The crude reaction mixture mixture was concentrated, and then dried under high vacuum to a constant mass giving 335 mg of the title compound as a HCL salt. LCMS (m/z): 335.1 (MH+), retention time=0.51 min.

Workup

  1. customThe crude reaction mixture mixture
  2. concentrationwas concentrated
  3. customdried under high vacuum to a constant mass

Sources & evidence

ORD record
ord-a605b0f956454dcba44b165b803dd67c
Source dataset
uspto-grants-2014_07
Patent number
US08778951B2

Reaction notes

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