Methyl 5-bromo-2-methylbenzoate → HCID 51033432, compound

HRID 1623431Notes

Reaction equation

HRID 1623431 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8](Br)[CH:7]=[CH:6][C:5]=1[CH3:11].[C:13]1(/[C:19](=[C:21]2/[C:22](=[O:30])[NH:23][C:24]3[C:29]/2=[CH:28][CH:27]=[CH:26][CH:25]=3)/[CH3:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([N:23]2[C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)/[C:21](=[C:19](\[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)/[CH3:20])/[C:22]2=[O:30])[CH:7]=[CH:6][C:5]=1[CH3:11]

Participants

3

Reactant 2

HCID 316201Methyl 5-bromo-2-methylbenzoateHCID 67043969HCID 67043969, compound

Product 1

HCID 51033432HCID 51033432, compound

Procedure

The title compound was prepared in analogy to Example 1 starting from 5-bromo-2-methyl-benzoic acid methyl ester (commercially available) and 3-[1-phenyl-eth-(E)-ylidene]-1,3-dihydro-indol-2-one. 1H NMR (400 MHz, chloroform-d) δppm 2.71 (s, 3H) 2.86 (s, 3H) 3.91 (s, 3H) 6.24 (d, J=7.83 Hz, 1H) 6.67-6.75 (m, 2H) 7.08 (t, J=7.83 Hz, 1H) 7.34-7.37 (m, 2H) 7.43-7.47 (m, 1H) 7.49-7.56 (m, 4H) 8.05 (d, J=2.27 Hz, 1H).

Sources & evidence

ORD record
ord-a03e829a358f4609b2687d0e949b45b3
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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