1-Chloro-4-iodobenzene → HCID 51033547, compound

HRID 1623440Notes

Reaction equation

HRID 1623440 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](=[O:38])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([C:26](=[O:37])[C:27]#[C:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:13]=1>>[CH3:9][O:10][C:11](=[O:38])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]2[C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)/[C:27](=[C:28](\[C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)/[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[O:35][CH3:36])/[C:26]2=[O:37])[CH:13]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67036327HCID 67036327, compound

Product 1

HCID 51033547HCID 51033547, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodo-benzene (commercially available) and 3-({[3-(2-methoxy-phenyl)-propynoyl]-phenyl-amino}-methyl)-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 7.99 (s, 1H), 7.92 (d, 1H), 7.26-7.49 (m, 7H), 6.93-7.15 (m, 4H), 6.72 (t, 1H), 6.61-6.64 (m, 2H), 4.93 (dd, 2H), 3.90 (s, 3H), 3.63 (s, 3H).

Sources & evidence

ORD record
ord-af1e595893fa428086b6bbb0e08f18ed
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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