1,3-Dichloro-5-iodobenzene → HCID 51033775, compound

HRID 1623449Notes

Reaction equation

HRID 1623449 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](I)[CH:5]=[C:4]([Cl:9])[CH:3]=1.[CH3:10][O:11][C:12](=[O:37])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:21](=[O:30])[C:22]#[C:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:14]=1>>[CH3:10][O:11][C:12](=[O:37])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)/[C:22](=[C:23](\[C:6]3[CH:7]=[C:2]([Cl:1])[CH:3]=[C:4]([Cl:9])[CH:5]=3)/[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)/[C:21]2=[O:30])[CH:14]=1

Participants

3

Reactant 2

HCID 764241,3-Dichloro-5-iodobenzeneHCID 670361553-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester

Product 1

HCID 51033775HCID 51033775, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1,3-dichloro-5-iodobenzene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (300 Hz, CDCl3): δppm 3.92 (s, 3H), 4.95 (s, 2H), 6.47 (d, 1H), 6.65-6.78 (m, 2H), 7.13 (t, 2H), 7.33-7.43 (m, 8H), 7.52 (d, 1H), 7.93 (d, 1H), 8.01 (s, 1H).

Sources & evidence

ORD record
ord-33216be31b7d427f8d86067c2a1929f3
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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