1,2-Dichloro-3-iodobenzene → HCID 51033776, compound

HRID 1623450Notes

Reaction equation

HRID 1623450 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](I)[C:3]=1[Cl:9].[CH3:10][O:11][C:12](=[O:37])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:21](=[O:30])[C:22]#[C:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:14]=1>>[CH3:10][O:11][C:12](=[O:37])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)/[C:22](=[C:23](\[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=3[Cl:9])/[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)/[C:21]2=[O:30])[CH:14]=1

Participants

3

Reactant 2

HCID 754591,2-Dichloro-3-iodobenzeneHCID 670361553-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester

Product 1

HCID 51033776HCID 51033776, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1,2-dichloro-3-iodobenzene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 8.00 (s, 1H), 7.92 (d, 1H), 7.33-7.54 (m, 9H), 7.23 (dd, 1H), 7.10 (t, 1H), 6.74 (t, 1H), 6.66 (d, 1H), 6.55 (d, 1H), 4.95 (s, 2H), 3.90 (s, 3H).

Sources & evidence

ORD record
ord-91c5a91db2754fa49955935e1542037b
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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