1-Chloro-4-iodobenzene → HCID 51033777, compound

HRID 1623451Notes

Reaction equation

HRID 1623451 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11](=[O:36])[C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:20](=[O:29])[C:21]#[C:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:14][CH:13]=1>>[CH3:9][O:10][C:11](=[O:36])[C:12]1[CH:13]=[CH:14][C:15]([CH2:18][N:19]2[C:30]3[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=3)/[C:21](=[C:22](\[C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)/[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)/[C:20]2=[O:29])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67036288HCID 67036288, compound

Product 1

HCID 51033777HCID 51033777, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodobenzene (commercially available) and 4-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 7.97 (d, 1H), 7.25-7.43 (m, 12H), 7.07 (dt, 1H), 6.71 (dt, 1H), 6.61 (d, 1H), 6.54 (d, 1H), 4.97 (s, 2H), 3.89 (s, 3H).

Sources & evidence

ORD record
ord-2ff9ea2f896142bab5ce96bf0983c641
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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