Benzene, 1-bromo-3-iodo- → HCID 51034988, compound

HRID 1623457Notes

Reaction equation

HRID 1623457 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](I)[CH:3]=1.[CH3:9][O:10][C:11](=[O:36])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:20](=[O:29])[C:21]#[C:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:13]=1>>[CH3:9][O:10][C:11](=[O:36])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]2[C:30]3[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=3)/[C:21](=[C:22](\[C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)/[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)/[C:20]2=[O:29])[CH:13]=1

Participants

3

Reactant 2

HCID 11561Benzene, 1-bromo-3-iodo-HCID 670361553-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester

Product 1

HCID 51034988HCID 51034988, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-bromo-3-iodobenzene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (CDCl3, 300 MHz) δppm 8.01 (s, 1H), 7.93 (d, 1H), 7.31-7.61 (m, 11H), 7.08 (t, 1H), 6.64-6.73 (m, 2H), 6.44 (d, 1H), 4.95 (s, 2H), 3.91 (s, 3H).

Sources & evidence

ORD record
ord-3dc57ef0620c47bb9a62758cbb6acbe8
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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