HCID 20080599, compound → HCID 58201665, compound

HRID 1623462Notes

Reaction equation

HRID 1623462 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([CH3:11])(=[O:10])=[O:9].[CH3:12][O:13][C:14](=[O:39])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:23](=[O:32])[C:24]#[C:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:16]=1>>[CH3:12][O:13][C:14](=[O:39])[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][N:22]2[C:33]3[C:38](=[CH:37][CH:36]=[CH:35][CH:34]=3)/[C:24](=[C:25](\[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[S:8]([CH3:11])(=[O:10])=[O:9])/[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)/[C:23]2=[O:32])[CH:16]=1

Participants

3

Reactant 2

HCID 20080599HCID 20080599, compoundHCID 670361553-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester

Product 1

HCID 58201665HCID 58201665, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-iodo-2-methanesulfonyl-benzene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (300 Hz, CDCl3): δppm 1.89 (s, 1.5H), 2.50 (s, 1.5H), 3.90 (s, 3H), 4.98 (dd, 2H), 5.98 (dd, 1H), 6.65-6.68 (m, 2H), 7.07 (m, 1H), 7.35-7.58 (m, 8H), 7.61 (t, 1H), 7.78 (t, 1H), 7.99 (d, 1H), 8.02 (d, 1H), 8.20 (d, 1H).

Sources & evidence

ORD record
ord-93bee9281c5b434a8fa99aca3de4cc15
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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