3-Iodothiophene → HCID 51033779, compound

HRID 1623463Notes

Reaction equation

HRID 1623463 reaction equation
I[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[CH3:7][O:8][C:9](=[O:34])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][N:17]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:18](=[O:27])[C:19]#[C:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:11]=1>>[CH3:7][O:8][C:9](=[O:34])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][N:17]2[C:28]3[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=3)/[C:19](=[C:20](/[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)\[C:2]3[CH:6]=[CH:5][S:4][CH:3]=3)/[C:18]2=[O:27])[CH:11]=1

Participants

3

Reactant 2

HCID 663323-IodothiopheneHCID 670361553-{[Phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester

Product 1

HCID 51033779HCID 51033779, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 3-iodo-thiophene (commercially available) and 3-{[phenyl-(3-phenyl propynoyl)-amino]-methyl}-benzoic acid methyl ester. 1H NMR (300 Hz, CDCl3): δppm 3.91 (s, 3H), 4.96 (s, 2H), 6.65 (d, 1H), 6.76-6.82 (m, 2H), 7.06-7.11 (m, 2H), 7.33-7.43 (m, 8H), 7.50 (d, 1H), 7.92 (d, 1H), 8.01 (s, 1H).

Sources & evidence

ORD record
ord-426023d38f3e4f3485e76a9b9cd1cb81
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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