1-Chloro-4-iodobenzene → HCID 51033439, compound

HRID 1623466Notes

Reaction equation

HRID 1623466 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH2:9]([O:11][C:12](=[O:39])[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:23](=[O:32])[C:24]#[C:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:17][CH:16]=1)[CH3:10]>>[CH2:9]([O:11][C:12](=[O:39])[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[C:33]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)/[C:24](=[C:25](\[C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)/[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)/[C:23]2=[O:32])=[CH:17][CH:16]=1)[CH3:10]

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67035975HCID 67035975, compound

Product 1

HCID 51033439HCID 51033439, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodo-benzene (commercially available) and (4-{[phenyl-(3-phenyl-propynoyl)-amino]-methyl}-phenoxy)-acetic acid ethyl ester. 1H NMR (300 Hz, CDCl3): δppm 1.28 (t, 3H), 4.26 (q, 2H), 4.57 (s, 2H), 4.84 (s, 2H), 6.51 (d, 1H), 6.67-6.71 (m, 2H), 6.83 (d, 2H), 7.08 (t, 1H), 7.24-7.42 (m, 11H).

Sources & evidence

ORD record
ord-ad358853dcc5447a96468eccf45c13d3
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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