1-Chloro-4-iodobenzene → HCID 51033892, compound

HRID 1623469Notes

Reaction equation

HRID 1623469 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH2:9]([O:11][C:12]([C:14]1[N:15]=[C:16]([CH2:19][N:20]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:21](=[O:30])[C:22]#[C:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[S:17][CH:18]=1)=[O:13])[CH3:10]>>[CH2:9]([O:11][C:12]([C:14]1[N:15]=[C:16]([CH2:19][N:20]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)/[C:22](=[C:23](\[C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)/[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)/[C:21]2=[O:30])[S:17][CH:18]=1)=[O:13])[CH3:10]

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67036267HCID 67036267, compound

Product 1

HCID 51033892HCID 51033892, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodo-benzene (commercially available) and 2-{[phenyl-(3-phenyl-propynoyl)-amino]-methyl}-thiazole-4-carboxylic acid ethyl ester. 1H NMR (300 Hz, CDCl3): δppm 1.39 (t, 3H), 4.44 (q, 2H), 5.27 (s, 2H), 6.58 (d, 1H), 6.78 (t, 1H), 6.88 (d, 1H), 7.13 (t, 1H), 7.31-7.43 (m, 9H), 8.10 (s, 1H).

Sources & evidence

ORD record
ord-c0cf3b95f9b34433adec1742c472d84c
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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