1-Chloro-4-iodobenzene → HCID 51033993, compound

HRID 1623470Notes

Reaction equation

HRID 1623470 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:34]=[CH:33][C:14]([CH2:15][N:16]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:17](=[O:26])[C:18]#[C:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][CH:12]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[C:19](=[C:18]2/[C:17](=[O:26])[N:16]([CH2:15][C:14]3[CH:13]=[CH:12][C:11]([O:10][CH3:9])=[CH:34][CH:33]=3)[C:27]3[C:32]/2=[CH:31][CH:30]=[CH:29][CH:28]=3)/[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 67036354HCID 67036354, compound

Product 1

HCID 51033993HCID 51033993, compound

Procedure

The title compound was prepared in analogy to Example 5 starting from 1-chloro-4-iodo-benzene (commercially available) and 3-phenyl-propynoic acid (4-methoxy-benzyl)-phenylamide. 1H NMR (300 Hz, CDCl3): δppm 3.77 (s, 3H), 4.88 (s, 2H), 6.53 (d, 1H), 6.67-6.71 (m, 2H), 6.80 (dd, 1H), 6.85-6.90 (m, 2H), 7.07 (t, 1H), 7.19-7.43 (m, 10H).

Sources & evidence

ORD record
ord-d5dcc345844049e4be46bf7e609ff4f5
Source dataset
uspto-grants-2014_07
Patent number
US08778973B2

Reaction notes

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